Osteoarticular Biobank

ACS Biotech offers high quality osteoarticular cells for R&D labs which focus on osteoarticular pathologies. Since 10 years, ACS Biotech has developed high expertise in collection, conservation and quality controls in ostearticular cells like chondrocytes, fibrochondrocytes, synoviocytes as well as ostearticular tissues like. It will be possible to study several osteoarticular tissues from the same patient.

 

ACS Biotech undertakes to provide cells, tissues or biological fluids controlled in terms of identity, purity, functionality and safety. All the quality controls will be carried out to ensure compliance with the expected requirements: appearance, number of cells, viability, morphology, phenotype, cell purity, sterility. All products test negative for mycolpasma, yeast, funghi, HIV-1, HIV-2, HBV, HCV, Syphillis BW and HTLV.

 

All these products are for R&D use only.

Products

Human joints are complex with different tissues. Each tissue has proper properties.

 

Articular Cartilage is composed of only one specialized cell type, the chondrocytes, which are dispersed in an extracellular matrix rich in type II collagen (giving resistance to the tissue) and in aggrecans (contributing to viscoelasticity).. The role of cartilage is to transmit and distribute loads during joint movements.

 

Meniscus are composed from fibrocartilage where the expression of type I collagen is higher than in hyaline cartilage. They are positioned on either side of the inner and outer compartments of the knee. They play the role of shock absorbers (with the ligaments) and ensure good stability of the knee.

 

Synovial Membrane is a connective tissue in contact with synovial fluid. Synovial membrane is composed of rouded-macrophage-like synovial cells (type A) and also fibroblast-like synoviocytes FLS (type B).Type A cells maintain the synovial fluid by removing wear-and-tear debris and FLS produce hyaluronan, as well as other extracellular components in the synovial fluid.

 

Synovial fluid is biological fluid produced by the synovial membrane. This liquid is viscous, transparent or pale yellow.

 

Human chondrocytes are isolated from normal human articular cartilage from the knee or hip joints.

 

Human fibrochondrocytes are isolated from human meniscus from the knee.

 

Human Synoviocytes are isolated from human synovial membrane from the knee.

 

a we guarantee more than 2 Million cells after cryopreservation

b before cryopreservation

Human Primary Chondrocytes

  • Cryovial : > 2 Million cells a
  • Format : Cryopreserved
  • Passage : P0- P1
  • QC :
    • Cell morpholgy
    • Viability : P0 >80% b / P1 >95% b
    • Q-PCR: Coll II > Coll I, ACAN
  • Doublings Times
  • Source : Knee/Hip

Human Primary Fibrochondrocytes

  • Cryovial : > 2 Millions cells a
  • Format : Cryopreserved
  • Passage : P0- P1
  • QC :
    • Cell morpholgy,
    • Viability P0 >75% b / P1 >95% b
    • Q-PCR: Coll2, Coll1, CDH11
  • Doubling Times
  • Source : Knee

Human Primary Synoviocytes

  • Cryovial : > 2 Millions cells a
  • Format : Cryopreserved
  • Passage : P4- P5
  • QC :
    • Cell morpholgy
    • Viability P4 >95% b/P5 >95% b
    • Q-PCR: CD90, FN1, CDH11
  • Doubling Times
  • Source : Knee

Human Cartilage Tissue

  • Weight : 1-2g
  • Format : Cryopreserved
  • QC : Aspect
  • Source : Knee/Hip

Human synovial membrane - liquid

  • Weight : 1-2g
  • Format : Cryopreserved
  • QC : Aspect
  • Source : Knee

Human meniscus

  • Weight : 1-2g
  • Format : Cryopreserved
  • QC : Aspect
  • Source : Knee

ACS Biotech is in compliance with the Regulation (EU) 2016/679 of the European Parliament and of the Council of April 27, 2016 on the protection of individuals with regard to the processing of personal data and on the free movement of this data (GDPR). The donation, supply and analyzes carried out on biological samples of human origin comply with directives 2004/23/EC (european parliament 2004), 2002/98/EC, 2006/17/EC (european parliament 2006), 2006/86/EC (Parliament 2006).

 

ACS Biotech built strategic partnerships with Dominique Dutscher and Clinisciences for the distribution of the osteoarticular tissues, cells and fluids.

 

Dutscher Clinisciences

ACS Biotech

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